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OverviewCovering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases. Full Product DetailsAuthor: Li He Zhang , Zhen Xi , Jyoti Chattopadhyaya , Sidney M. HechtPublisher: John Wiley and Sons Ltd Imprint: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd) Country of Publication: United Kingdom Dimensions: Width: 16.30cm , Height: 2.70cm , Length: 24.20cm Weight: 0.786kg ISBN: 9780470596685ISBN 10: 0470596686 Pages: 448 Publication Date: 30 September 2011 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Available  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. Table of ContentsFOREWORD vii CONTRIBUTORS xi INTRODUCTION xv 1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY 1 Jianing Wang, Ravindra K. Rawal, and Chung K. Chu 2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES 101 Wen Zhang, Jia Sheng, and Zhen Huang 3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 142 Hon Cheung Lee 4 DNA AND RNA BINDING SMALL MOLECULES 164 Shibo Li and Zhen Xi 5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY 206 Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu 6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN 258 Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang 7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO-A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME 272 Oleksandr Plashkevych and Jyoti Chattopadhyaya 8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE 292 Il Joon Lee and Byeang Hyean Kim 9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS 335 Rakesh N. Veedu and Jesper Wengel 10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349 Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, and Ying Wang 11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390 Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou 12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405 Quan Du, Huang Huang, and Zicai Liang INDEX 423ReviewsAuthor InformationLI-HE ZHANG is President of the academic committee of State Key Laboratory of Natural and Biomimetic Drugs, as well as Professor of Medicinal Chemistry at Peking University. He is also a member of the Chinese Academy of Sciences, Fellow of the Royal Society of Chemistry, former vice president of the Chinese Pharmaceutical Association, and past president of the Asian Federation of Medicinal Chemistry. ZHEN XI, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles. JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals. Tab Content 6Author Website:Countries AvailableAll regions |
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