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OverviewThe effect of centrally administered losartan, an angiotensin-2 receptor antagonist on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers such as acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol induced and stress induce acute gastric ulcer and cysteamine hydrochloride induced duodenal ulcer. Losartan was administered intracerebroventrically at two different doses of 125 micro gm/kg and 250 micro gm/kg. Both doses of losartan increased healing of ulcer in acetic acid induced chronic gastric ulcer model. In pylorus legated rats, a significant reduction in free acidity, total acidity and ulcer index was observed with high dose while low dose produced reduction in free acidity and ulcer index. Both doses also showed significant antiulcer effect in ethanol-induced and stress-induced gastric ulcers. Losartan also reduced ulcer area in cysteamine-induced duodenal ulcer. It was concluded that angiotensin II receptor antagonism in brain increases healing of gastric ulcers and also prevents development of gastric and duodenal ulcers in rats. Full Product DetailsAuthor: Ankit MeraiPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Country of Publication: United States Dimensions: Width: 15.20cm , Height: 0.40cm , Length: 22.90cm Weight: 0.104kg ISBN: 9783846512296ISBN 10: 384651229 Pages: 64 Publication Date: 24 October 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: Not yet available This item is yet to be released. You can pre-order this item and we will dispatch it to you upon it's release. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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