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Effect of Losartan on Gastric and Duodenal Ulcers in Rats

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Effect of Losartan on Gastric and Duodenal Ulcers in Rats

Author:   Ankit Merai
Publisher:   LAP Lambert Academic Publishing
ISBN:  

9783846512296


Pages:   64
Publication Date:   24 October 2011
Format:   Paperback
Availability:   Not yet available   Availability explained
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon it's release.
Online Price $83.95 RRP $98.74 Save $14.79 (15.00%) Quantity:  
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Overview

The effect of centrally administered losartan, an angiotensin-2 receptor antagonist on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers such as acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol induced and stress induce acute gastric ulcer and cysteamine hydrochloride induced duodenal ulcer. Losartan was administered intracerebroventrically at two different doses of 125 micro gm/kg and 250 micro gm/kg. Both doses of losartan increased healing of ulcer in acetic acid induced chronic gastric ulcer model. In pylorus legated rats, a significant reduction in free acidity, total acidity and ulcer index was observed with high dose while low dose produced reduction in free acidity and ulcer index. Both doses also showed significant antiulcer effect in ethanol-induced and stress-induced gastric ulcers. Losartan also reduced ulcer area in cysteamine-induced duodenal ulcer. It was concluded that angiotensin II receptor antagonism in brain increases healing of gastric ulcers and also prevents development of gastric and duodenal ulcers in rats.

Full Product Details

Author:   Ankit Merai
Publisher:   LAP Lambert Academic Publishing
Imprint:   LAP Lambert Academic Publishing
Country of Publication:   United States
Dimensions:   Width: 15.20cm , Height: 0.40cm , Length: 22.90cm
Weight:   0.104kg
ISBN:  

9783846512296


ISBN 10:   384651229
Pages:   64
Publication Date:   24 October 2011
Audience:   General/trade ,  General
Format:   Paperback
Publisher's Status:   Active
Availability:   Not yet available   Availability explained
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon it's release.

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