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OverviewBenzodiazepines (BZs) were reported to protect against ethanol-induced gastric damage in rat's in vivo and in vitro model. However, the effects of some drugs in the new in vitro model do not agree with the results reported before in vivo studies. Therefore, the present study was designed to modify the new in vitro model and to assess the gastroprotective effects of some BZs, and also some new compounds. Gastric mucosal damage was induced by instillation of ethanol into the isolated rat stomach kept in aerated Kreb's solution at 37 C in an organ bath. Drugs or their vehicles were administered inside the bath 15 min before ethanol. The results indicated that gastric mucosal damage was significantly reduced by clonazepam, as well as by Ro 15-4513 (partial BZR inverse agonists) pretreatment, significantly reversed by flumazenil (a central BZR antagonist). CGS 9896 (a partial agonist at the BZRs) and Ro 5-3663 (an atypical BZ, which bind to the picrotoxin site) did not offer any protection against ethanol. The results suggest a local, gastric mediation of ethanol effect and the gastric protective action of BZs through their action on a local, central-type BZRs located in rats stomach Full Product DetailsAuthor: Hiwa K SaaedPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Country of Publication: United States Dimensions: Width: 15.20cm , Height: 0.60cm , Length: 22.90cm Weight: 0.159kg ISBN: 9783846511237ISBN 10: 3846511234 Pages: 100 Publication Date: 04 October 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: Not yet available  This item is yet to be released. You can pre-order this item and we will dispatch it to you upon it's release. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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