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OverviewA balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: * Risk and benefit analysis for toxicity and efficacy trade-offs * Bayesian predictive probability trial monitoring * Bayesian adaptive randomization * Late onset toxicity and response * Dose finding in drug combination trials * Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work. Full Product DetailsAuthor: Guosheng YinPublisher: John Wiley and Sons Ltd Imprint: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd) Country of Publication: United Kingdom Dimensions: Width: 15.70cm , Height: 2.40cm , Length: 24.10cm Weight: 0.646kg ISBN: 9780470581711ISBN 10: 0470581719 Pages: 364 Publication Date: 09 February 2012 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Available  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. Table of ContentsReviewsAuthor InformationGUOSHENG YIN, PhD, is Associate Professor in the Department of Statistics and Actuarial Science at The University of Hong Kong, and Adjunct Associate Professor in the Department of Biostatistics at The University of Texas MD Anderson Cancer Center. Tab Content 6Author Website:Countries AvailableAll regions |
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